靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T51452

FORMERID

TTDR01177

UNIPROID

GBRA2_HUMAN

TARGNAME

GABA(A) receptor alpha-2 (GABRA2)

GENENAME

GABRA2

TARGTYPE

Successful target

SYNONYMS

GABRA2; GABA-A receptor alpha 2; GABA(A)Gamma-aminobutyric-acid receptor alpha-2 subunit precursor receptor

FUNCTION

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP

DRUGINFO

Flumazenil

DRUGINFO

GSK683699

DRUGINFO

PF-4480682

Discontinued in Phase 2

DRUGINFO

D06BFP

CGS-17867A

Terminated

DRUGINFO

D09ACO

(2E,4S)-4-ammoniopent-2-enoate

Investigative

DRUGINFO

D0A8EU

(4R)-4-ammoniopentanoate

Investigative

DRUGINFO

D0N0ZK

(4S)-4-ammoniopentanoate

Investigative

DRUGINFO

D07JXC

[18F]fluoroethylflumazenil

DRUGINFO

[35S]TBPS

DRUGINFO

[3H]CGS8216

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04723	Retrograde endocannabinoid signaling
hsa04727	GABAergic synapse
hsa05032	Morphine addiction
hsa05033	Nicotine addiction

目标的 Wiki 路径数据

标题	内容
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2670	Iron uptake and transport

目标的蛋白质ID

标题	内容
TARGETID	T51452
UNIPROID	GBRA2_HUMAN
TARGNAME	GABA(A) receptor alpha-2 (GABRA2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
GABA(A) receptor alpha-2 (GABRA2)	MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP

标题

内容

GABA(A) receptor alpha-2 (GABRA2)

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