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靶点信息54(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Kynurenine 3-hydroxylase (KMO)
TARGTYPE
Clinical trial target
SYNONYMS
Kynurenine 3monooxygenase; Kynurenine 3-monooxygenase
FUNCTION
Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).
BIOCLASS
Paired donor oxygen oxidoreductase
SEQUENCE
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
DRUGINFO
Aryl pyrimidine derivative 2
DRUGINFO
Aryl pyrimidine derivative 3
DRUGINFO
Aryl pyrimidine derivative 4
DRUGINFO
Aryl pyrimidine derivative 5
DRUGINFO
Aryl pyrimidine derivative 6
DRUGINFO
Aryl pyrimidine derivative 7
DRUGINFO
Aryl pyrimidine derivative 8
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Kynurenine 3-hydroxylase (KMO) |
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