TARGETID

T50912

FORMERID

TTDS00490

UNIPROID

CD86_HUMAN

TARGNAME

T-lymphocyte activation antigen CD86 (FUN1)

GENENAME

CD86

TARGTYPE

Successful target

SYNONYMS

FUN-1; CTLA-4 counter-receptor B7.2; CD86; CD28LG2; BU63; B70; Activation B7-2 antigen

FUNCTION

Receptor involved in the costimulatory signal essential for t-lymphocyte proliferation and interleukin-2 production, by binding cd28 or ctla-4. May play a critical role in the early events of t-cell activation and costimulationof naive t-cells, such as deciding between immunity and anergy that is made by t-cells within 24 hours after activation. Isoform 2 interferes with the formation of cd86 clusters, and thus acts as a negative regulator of t-cell activation.

PDBSTRUC

5YXK; 1NCN; 1I85

BIOCLASS

Immunoglobulin

SEQUENCE

MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF

DRUGINFO

Abatacept

DRUGINFO

MAXY-4

DRUGINFO

Tolerimab

KEGGPATH

hsa04514:Cell adhesion molecules (CAMs)

KEGGPATH

hsa04620:Toll-like receptor signaling pathway

KEGGPATH

hsa04672:Intestinal immune network for IgA production

KEGGPATH

hsa04940:Type I diabetes mellitus

KEGGPATH

hsa05202:Transcriptional misregulation in cancer

KEGGPATH

hsa05320:Autoimmune thyroid disease