TARGETID

T47387

FORMERID

TTDI02260

UNIPROID

BCL2_HUMAN

TARGNAME

BCL-2 messenger RNA (BCL2 mRNA)

GENENAME

BCL2

TARGTYPE

Clinical trial target

SYNONYMS

Bcl-2 (mRNA); Apoptosis regulator Bcl-2 (mRNA)

FUNCTION

Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells.

PDBSTRUC

6GL8; 5VAY; 5VAX; 5VAU; 5JSN

BIOCLASS

mRNA target

SEQUENCE

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

DRUGINFO

PNT-2258

DRUGINFO

Beclanorsen

DRUGINFO

BP1002

DRUGINFO

BP-100-1.02

DRUGINFO

G3139 + cytarabine (ARA-C)

DRUGINFO

G3139 + Dacarbazine

DRUGINFO

G3139 + Dexamethasone

DRUGINFO

G3139 + Fludarabine

DRUGINFO

G3139 + G-CSF