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靶点信息

标题

内容

相关药物

状态

TARGETID

T47081

FORMERID

TTDS00323

UNIPROID

PPIA_HUMAN

TARGNAME

Rotamase A (PPIA)

GENENAME

PPIA

TARGTYPE

Successful target

SYNONYMS

PPIA; Cyclophilin A; CyPA

FUNCTION

Ppiases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

PDBSTRUC

6GJY; 6GJR; 6GJP; 6GJN; 6GJM

BIOCLASS

Cis-trans-isomerases

ECNUMBER

EC 5.2.1.8

SEQUENCE

MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE

DRUGINFO

D0DZ3X

L-Proline

Approved

DRUGINFO

D0DQ4D

(3r)-1-Acetyl-3-Methylpiperidine

Investigative

DRUGINFO

D0P6TX

1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea

Investigative

DRUGINFO

D07IQR

3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide

Investigative

DRUGINFO

D0X5JR

4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide

Investigative

DRUGINFO

D0L5XK

7-AMINO-4-METHYL-CHROMEN-2-ONE

Investigative

DRUGINFO

D0P8IK

Ethyl Oxo(Piperidin-1-Yl)Acetate

Investigative

WIKIPATH

WP1794:Cell surface interactions at the vascular wall

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容
WP2746	Signaling by the B Cell Receptor (BCR)
WP2684	Host Interactions of HIV factors
WP2658	HIV Life Cycle
WP2593	JAK/STAT
WP1794	Cell surface interactions at the vascular wall

目标的蛋白质ID

标题	内容
TARGETID	T47081
UNIPROID	PPIA_HUMAN
TARGNAME	Rotamase A (PPIA)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Rotamase A (PPIA)	MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE

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