靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T44282

FORMERID

TTDR01185

UNIPROID

ALDH2_HUMAN

TARGNAME

Mitochondrial aldehyde dehydrogenase (ALDH2)

GENENAME

ALDH2

TARGTYPE

Clinical trial target

SYNONYMS

Aldehyde dehydrogenase, mitochondrial; ALDM; ALDHI; ALDH-E2; ALDH class 2

FUNCTION

Second enzyme of the major oxidative pathway of alcohol metabolism. Catalyzes the chemical transformation from acetaldehyde to acetic acid. Additionally, functions as a protector against oxidative stress.

PDBSTRUC

5L13; 4KWG; 4KWF; 4FR8; 4FQF

BIOCLASS

Aldehyde/oxo donor oxidoreductase

ECNUMBER

EC 1.2.1.3

SEQUENCE

MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

DRUGINFO

ALD-401

DRUGINFO

ANS-6637

DRUGINFO

FP-045

DRUGINFO

GS-6637

DRUGINFO

Daidzin

DRUGINFO

crotylaldehyde

DRUGINFO

CVT-10216

DRUGINFO

ISOFORMONENTIN

目标的 KEGG 通路数据

标题	内容
hsa00010	Glycolysis / Gluconeogenesis
hsa00040	Pentose and glucuronate interconversions
hsa00053	Ascorbate and aldarate metabolism
hsa00071	Fatty acid degradation
hsa00280	Valine, leucine and isoleucine degradation
hsa00310	Lysine degradation
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00380	Tryptophan metabolism
hsa00410	beta-Alanine metabolism
hsa00561	Glycerolipid metabolism
hsa00620	Pyruvate metabolism
hsa01100	Metabolic pathways
hsa01130	Biosynthesis of antibiotics

目标的 Wiki 路径数据

标题	内容
WP465	Tryptophan metabolism
WP206	Fatty Acid Omega Oxidation
WP1879	Phase 1 - Functionalization of compounds
WP1870	Neurotransmitter Clearance In The Synaptic Cleft

目标的蛋白质ID

标题	内容
TARGETID	T44282
UNIPROID	ALDH2_HUMAN
TARGNAME	Mitochondrial aldehyde dehydrogenase (ALDH2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Mitochondrial aldehyde dehydrogenase (ALDH2)	MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

标题

内容

Mitochondrial aldehyde dehydrogenase (ALDH2)

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