TARGETID

T44068

FORMERID

TTDS00036

UNIPROID

ADRB1_HUMAN

TARGNAME

Adrenergic receptor beta-1 (ADRB1)

GENENAME

ADRB1

TARGTYPE

Successful target

SYNONYMS

Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R

FUNCTION

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

PDBSTRUC

2LSQ

BIOCLASS

GPCR rhodopsin

SEQUENCE

MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV

DRUGINFO

Acebutolol

DRUGINFO

Ajmalicine

DRUGINFO

Anisodamine

DRUGINFO

Anisodine

DRUGINFO

Arbutamine

DRUGINFO

Atenolol

DRUGINFO

Betaxolol

DRUGINFO

Bisoprolol

DRUGINFO

Bretylium