靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T42000

FORMERID

TTDS00447

UNIPROID

IL1B_HUMAN

TARGNAME

Interleukin-1 beta (IL1B)

GENENAME

IL1B

TARGTYPE

Successful target

SYNONYMS

IL1F2; IL-1beta; IL-1 beta; Catabolin

FUNCTION

Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Potent proinflammatory cytokine.

PDBSTRUC

9ILB; 7I1B; 6I1B; 5MVZ; 5I1B

BIOCLASS

Cytokine: interleukin

SEQUENCE

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

DRUGINFO

Canakinumab

DRUGINFO

Gallium nitrate

DRUGINFO

Glucosamine

DRUGINFO

Rilonacept

DRUGINFO

Diacerein

DRUGINFO

XOMA 052

DRUGINFO

ABT-981

DRUGINFO

AC-201

DRUGINFO

LY-2189102

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04064	NF-kappa B signaling pathway
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04640	Hematopoietic cell lineage
hsa04668	TNF signaling pathway
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04940	Type I diabetes mellitus
hsa05010	Alzheimer's disease
hsa05020	Prion diseases
hsa05132	Salmonella infection
hsa05133	Pertussis
hsa05134	Legionellosis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05143	African trypanosomiasis
hsa05144	Malaria
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05162	Measles
hsa05164	Influenza A
hsa05168	Herpes simplex infection
hsa05321	Inflammatory bowel disease (IBD)
hsa05323	Rheumatoid arthritis
hsa05332	Graft-versus-host disease

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP727	Monoamine Transport
WP706	SIDS Susceptibility Pathways
WP69	TCR Signaling Pathway
WP619	Type II interferon signaling (IFNG)
WP615	Senescence and Autophagy in Cancer
WP530	Cytokines and Inflammatory Response
WP382	MAPK Signaling Pathway
WP289	Myometrial Relaxation and Contraction Pathways
WP2873	Aryl Hydrocarbon Receptor Pathway
WP2865	IL1 and megakaryotyces in obesity
WP2849	Hematopoietic Stem Cell Differentiation
WP2431	Spinal Cord Injury
WP2328	Allograft Rejection
WP2059	Alzheimers Disease
WP2034	Leptin signaling pathway
WP195	IL-1 signaling pathway
WP1839	Interleukin-1 signaling
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network
WP1455	Serotonin Transporter Activity
WP1449	Regulation of toll-like receptor signaling pathway
WP1433	NOD pathway

目标的蛋白质ID

标题	内容
TARGETID	T42000
UNIPROID	IL1B_HUMAN
TARGNAME	Interleukin-1 beta (IL1B)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Interleukin-1 beta (IL1B)	MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

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