TARGETID

T40787

FORMERID

TTDR00959

UNIPROID

MTAP_HUMAN

TARGNAME

S-methyl-5'-thioadenosine phosphorylase (MTAP)

GENENAME

MTAP

TARGTYPE

Literature-reported target

SYNONYMS

Methylthioadenosine phosphorylase; MTAPase; MTA phosphorylase; MSAP; 5'-methylthioadenosine phosphorylase

FUNCTION

Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.

PDBSTRUC

6DZ3; 6DZ2; 6DZ0; 6DYZ; 5TC8

BIOCLASS

Glycosyltransferases

ECNUMBER

EC 2.4.2.28

SEQUENCE

MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH

DRUGINFO

METHYLTHIOADENOSINE

DRUGINFO

5'-Deoxy-5'-(Methylthio)-Tubercidin

DRUGINFO

Formycin

KEGGPATH

hsa00270:Cysteine and methionine metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP2693:Metabolism of amino acids and derivatives

WHIZPATH

PW000056:Methionine Metabolism

BIOCPATH

PWY-6756:S-methyl-5'-thioadenosine degradation