TARGETID

T40696

FORMERID

TTDS00083

UNIPROID

PARC_STAAS

TARGNAME

Staphylococcus Topoisomerase IV (Stap-coc parC)

GENENAME

Stap-coc parC

TARGTYPE

Successful target

SYNONYMS

Topoisomerase IV subunit A; DNA topoisomerase 4 subunit A

FUNCTION

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

PDBSTRUC

2INR

BIOCLASS

Topoisomerase GyrA ParC

ECNUMBER

EC 5.6.2.3

SEQUENCE

MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVVTEGVSENDTILMATQRGSLKRISFKILQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYTNGSFIVDTDDFGEVIDMYIS

DRUGINFO

Besifloxacin

DRUGINFO

Ciprofloxacin XR

DRUGINFO

Delafloxacin Meglumine

DRUGINFO

Finafloxacin

DRUGINFO

Gatifloxacin

DRUGINFO

Gemifloxacin

DRUGINFO

Levofloxacin

DRUGINFO

Moxifloxacin