TARGETID

T40628

FORMERID

TTDS00055

UNIPROID

3BHS1_HUMAN; 3BHS2_HUMAN

TARGNAME

Hydroxysteroid dehydrogenase 3-beta (HSD3B)

GENENAME

HSD3B1; HSD3B2

TARGTYPE

Literature-reported target

SYNONYMS

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

FUNCTION

Catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17-hydroxyprogesterone from 17-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. Also catalyzes the oxidative conversion of 5-3-hydroxysteroids to the 4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.

BIOCLASS

Short-chain dehydrogenases reductase

SEQUENCE

MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ

DRUGINFO

17 beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one (4MA)

DRUGINFO

2-Sulfhydryl-Ethanol

DRUGINFO

4-ANDROSTENE-3-17-DIONE

DRUGINFO

4-MA

DRUGINFO

5alpha-Androstan-3,17-Dione

DRUGINFO

Epostane

DRUGINFO

Equilenin