TARGETID

T40491

FORMERID

TTDI00641

UNIPROID

PP2AA_HUMAN

TARGNAME

Serine/threonine PP2A-alpha (PPP2CA)

GENENAME

PPP2CA

TARGTYPE

Clinical trial target

SYNONYMS

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Replication protein C; RP-C; PP2A-alpha

FUNCTION

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. PP2A is the major phosphatase for microtubule-associated proteins (MAPs).

PDBSTRUC

5W0W; 4LAC; 4IYP; 4I5N; 4I5L

BIOCLASS

Phosphoric monoester hydrolase

ECNUMBER

EC 3.1.3.16

SEQUENCE

MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

DRUGINFO

VP-102

DRUGINFO

LB-100

KEGGPATH

hsa03015:mRNA surveillance pathway

KEGGPATH

hsa04071:Sphingolipid signaling pathway

KEGGPATH

hsa04114:Oocyte meiosis

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04152:AMPK signaling pathway

KEGGPATH

hsa04261:Adrenergic signaling in cardiomyocytes