靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T40045

FORMERID

TTDI02344

UNIPROID

RIR1_HUMAN

TARGNAME

RRM1 messenger RNA (RRM1 mRNA)

GENENAME

RRM1

TARGTYPE

Discontinued target

SYNONYMS

Ribonucleotide reductase large subunit (mRNA); Ribonucleoside-diphosphate reductase subunit M1 (mRNA); Ribonucleoside-diphosphate reductase large subunit (mRNA); RR1 (mRNA)

FUNCTION

Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Provides the precursors necessary for DNA synthesis.

PDBSTRUC

6AUI; 5TUS; 5D1Y; 4X3V; 3HNF

BIOCLASS

mRNA target

ECNUMBER

EC 1.17.4.1

SEQUENCE

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

DRUGINFO

D0K4OL

LOR-2501

Discontinued in Phase 1

KEGGPATH

hsa00230:Purine metabolism

KEGGPATH

hsa00240:Pyrimidine metabolism

KEGGPATH

hsa00480:Glutathione metabolism

KEGGPATH

hsa01100:Metabolic pathways

WIKIPATH

WP1601:Fluoropyrimidine Activity

WIKIPATH

WP1851:Metabolism of nucleotides

WIKIPATH

WP2377:Integrated Pancreatic Cancer Pathway

目标的 KEGG 通路数据

标题	内容
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways

目标的 Wiki 路径数据

标题	内容
WP404	Nucleotide Metabolism
WP2446	Retinoblastoma (RB) in Cancer
WP2377	Integrated Pancreatic Cancer Pathway
WP1851	Metabolism of nucleotides
WP1601	Fluoropyrimidine Activity

目标的蛋白质ID

标题	内容
TARGETID	T40045
UNIPROID	RIR1_HUMAN
TARGNAME	RRM1 messenger RNA (RRM1 mRNA)
TARGTYPE	Discontinued target

目标的序列数据

标题	内容
RRM1 messenger RNA (RRM1 mRNA)	MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS

标题

内容

RRM1 messenger RNA (RRM1 mRNA)

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