TARGETID

T39797

FORMERID

TTDI02075

UNIPROID

FZD7_HUMAN

TARGNAME

Frizzled-7 receptor (FZD7)

GENENAME

FZD7

TARGTYPE

Clinical trial target

SYNONYMS

hFz7; FzE3; Fz7; Fz-7; Frizzled7; Frizzled-7

FUNCTION

Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Receptor for Wnt proteins.

PDBSTRUC

6O3B; 6O3A; 6NE4; 6NE2; 5WBS

BIOCLASS

GPCR frizzled

SEQUENCE

MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV

DRUGINFO

OMP-18R5

KEGGPATH

hsa04310:Wnt signaling pathway

KEGGPATH

hsa04390:Hippo signaling pathway

KEGGPATH

hsa04550:Signaling pathways regulating pluripotency of stem cells

KEGGPATH

hsa04916:Melanogenesis

KEGGPATH

hsa05166:HTLV-I infection

KEGGPATH

hsa05200:Pathways in cancer

KEGGPATH

hsa05205:Proteoglycans in cancer

KEGGPATH

hsa05217:Basal cell carcinoma