TARGETID

T39321

FORMERID

TTDR00995

UNIPROID

G3P_HUMAN

TARGNAME

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

GENENAME

GAPDH

TARGTYPE

Clinical trial target

SYNONYMS

Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047

FUNCTION

Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.

PDBSTRUC

6ADE; 4WNI; 4WNC; 3GPD; 2FEH

BIOCLASS

Aldehyde/oxo donor oxidoreductase

ECNUMBER

EC 1.2.1.12

SEQUENCE

MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

DRUGINFO

Omigapil

DRUGINFO

Saframycin A

KEGGPATH

hsa00010:Glycolysis / Gluconeogenesis

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa01130:Biosynthesis of antibiotics

KEGGPATH

hsa01200:Carbon metabolism

KEGGPATH

hsa01230:Biosynthesis of amino acids

KEGGPATH

hsa04066:HIF-1 signaling pathway