TARGETID

T39087

FORMERID

TTDC00211

UNIPROID

POL_HV1B1

TARGNAME

Human immunodeficiency virus Integrase (HIV IN)

GENENAME

HIV IN

TARGTYPE

Successful target

SYNONYMS

HIV IN

FUNCTION

Gag-Pol polyprotein: Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation.

PDBSTRUC

6OE3; 6HAK; 6ELI; 6DUH; 6DUG

BIOCLASS

Integrase

ECNUMBER

EC 2.7.7.-

SEQUENCE

FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

DRUGINFO

Bictegravir, emtricitabine and tenofovir alafenamide

DRUGINFO

Dolutegravir

DRUGINFO

Elvitegravir

DRUGINFO

Raltegravir

DRUGINFO

GSK1265744

DRUGINFO

S-1360

DRUGINFO

S-364735

DRUGINFO

Acriflavine