TARGETID

T36959

FORMERID

TTDC00338

UNIPROID

ACVL1_HUMAN

TARGNAME

Activin receptor-like kinase-1 (ACVRL1)

GENENAME

ACVRL1

TARGTYPE

Clinical trial target

SYNONYMS

Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; ACVRLK1; ACVRL1

FUNCTION

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bindactivin as well.

PDBSTRUC

4FAO; 3MY0; 2LCR

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.30

SEQUENCE

MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ

DRUGINFO

PF-03446962

DRUGINFO

LDN-214117

DRUGINFO

ML347

DRUGINFO

PMID23639540C13a

DRUGINFO

PMID23639540C13d

DRUGINFO

PMID23639540C13r

INTEPATH

alk1_2pathway:ALK1 pathway

INTEPATH

alk1pathway:ALK1 signaling events