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靶点信息14(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
p53-binding protein Mdm4 (MDM4)
TARGTYPE
Clinical trial target
SYNONYMS
Protein Mdmx; Mdm2-like p53-binding protein; Double minute 4 protein
FUNCTION
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
PDBSTRUC
6Q9Y; 6Q9W; 6Q9U; 6Q9S; 6Q9Q
BIOCLASS
MDM2/MDM4 family
SEQUENCE
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
KEGGPATH
hsa04115:p53 signaling pathway
KEGGPATH
hsa05206:MicroRNAs in cancer
目标的蛋白质ID
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目标的序列数据
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| p53-binding protein Mdm4 (MDM4) |
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