靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T36483

FORMERID

TTDC00071

UNIPROID

PAR1_HUMAN

TARGNAME

Proteinase activated receptor 1 (F2R)

GENENAME

F2R

TARGTYPE

Successful target

SYNONYMS

Thrombin receptor; Proteinase-activated receptor 1; Protease-activated receptor-1; Protease activated receptor 1; PAR1; PAR-1; Coagulation factor II receptor; CF2R

FUNCTION

May play a role in platelets activation and in vascular development. High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

PDBSTRUC

3VW7; 3LU9; 3HKJ; 3HKI; 3BEF

BIOCLASS

GPCR rhodopsin

SEQUENCE

MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

DRUGINFO

Vorapaxar

DRUGINFO

E5555

DRUGINFO

PZ-128

DRUGINFO

FR-171113

DRUGINFO

RWJ-58259

DRUGINFO

RWJ-56110

DRUGINFO

SCH-205831

DRUGINFO

SCH-602539

KEGGPATH

hsa04015:Rap1 signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04015	Rap1 signaling pathway
hsa04020	Calcium signaling pathway
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04144	Endocytosis
hsa04151	PI3K-Akt signaling pathway
hsa04610	Complement and coagulation cascades
hsa04611	Platelet activation
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer

目标的 Wiki 路径数据

标题	内容
WP558	Complement and Coagulation Cascades
WP51	Regulation of Actin Cytoskeleton
WP455	GPCRs, Class A Rhodopsin-like
WP2865	IL1 and megakaryotyces in obesity
WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
WP2849	Hematopoietic Stem Cell Differentiation
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1929	Thrombin signalling through proteinase activated receptors (PARs)
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T36483
UNIPROID	PAR1_HUMAN
TARGNAME	Proteinase activated receptor 1 (F2R)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Proteinase activated receptor 1 (F2R)	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

标题

内容

Proteinase activated receptor 1 (F2R)

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