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靶点信息18(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cytosine deaminase (AICDA)
TARGTYPE
Clinical trial target
SYNONYMS
Activationinduced cytidine deaminase; AICDA
FUNCTION
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
PDBSTRUC
5W1C; 5W0Z; 5W0U; 5W0R; 5JJ4
BIOCLASS
Carbon-nitrogen hydrolase
SEQUENCE
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL
KEGGPATH
hsa04672:Intestinal immune network for IgA production
KEGGPATH
hsa05340:Primary immunodeficiency
NET_PATH
NetPath_16:IL4 Signaling Pathway
NET_PATH
NetPath_5:ID Signaling Pathway
INTEPATH
il4_2pathway:IL4-mediated signaling events
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Cytosine deaminase (AICDA) |
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