TARGETID

T36075

FORMERID

TTDS00440

UNIPROID

GLP1R_HUMAN

TARGNAME

Glucagon-like peptide 1 receptor (GLP1R)

GENENAME

GLP1R

TARGTYPE

Successful target

SYNONYMS

GLP-1R; GLP-1-R; GLP-1 receptor

FUNCTION

Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1).

PDBSTRUC

6GB1; 6B3J; 5VEX; 5VEW; 5OTX

BIOCLASS

GPCR secretin

SEQUENCE

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

DRUGINFO

Albiglutide

DRUGINFO

Dulaglutide

DRUGINFO

Exenatide

DRUGINFO

Liraglutide

DRUGINFO

Lixisenatide

DRUGINFO

Pramlintide

DRUGINFO

Semaglutide

DRUGINFO

Efpeglenatide

DRUGINFO

GLP-1