靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

WIKIPATH

WP75:Toll-like receptor signaling pathway

WHIZPATH

PW000453:Fc Epsilon Receptor I Signaling in Mast Cells

WHIZPATH

PW000454:Insulin Signalling

REACPATH

R-HSA-110056:MAPK3 (ERK1) activation

REACPATH

R-HSA-5210891:Uptake and function of anthrax toxins

REACPATH

R-HSA-5673000:RAF activation

REACPATH

R-HSA-5674135:MAP2K and MAPK activation

REACPATH

R-HSA-5674499:Negative feedback regulation of MAPK pathway

REACPATH

R-HSA-5684264:MAP3K8 (TPL2)-dependent MAPK1/3 activation

NET_PATH

NetPath_25:FSH Signaling Pathway

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway

INTEPATH

anthraxpathway:Cellular roles of Anthrax toxin

INTEPATH

ar_nongenomic_pathway:Nongenotropic Androgen signaling

INTEPATH

bcr_5pathway:BCR signaling pathway

INTEPATH

cd8tcrdownstreampathway:Downstream signaling in naïve CD8+ T cells

INTEPATH

ceramide_pathway:Ceramide signaling pathway

INTEPATH

cxcr3pathway:CXCR3-mediated signaling events

INTEPATH

endothelinpathway:Endothelins

INTEPATH

ephbfwdpathway:EPHB forward signaling

INTEPATH

erbb1_downstream_pathway:ErbB1 downstream signaling

目标的 KEGG 通路数据

标题	内容
hsa04921	Oxytocin signaling pathway
hsa05020	Prion diseases
hsa05034	Alcoholism
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04024	cAMP signaling pathway
hsa04062	Chemokine signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04114	Oocyte meiosis
hsa04151	PI3K-Akt signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04320	Dorso-ventral axis formation
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04540	Gap junction
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04620	Toll-like receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04668	TNF signaling pathway
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04725	Cholinergic synapse
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04915	Estrogen signaling pathway
hsa04916	Melanogenesis
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP734	Serotonin Receptor 4/6/7 and NR3C Signaling
WP732	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP722	Serotonin HTR1 Group and FOS Pathway
WP712	Estrogen signaling pathway
WP69	TCR Signaling Pathway
WP673	ErbB Signaling Pathway
WP666	Hypothetical Network for Drug Addiction
WP615	Senescence and Autophagy in Cancer
WP581	EPO Receptor Signaling
WP51	Regulation of Actin Cytoskeleton
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP437	EGF/EGFR Signaling Pathway
WP422	MAPK Cascade
WP382	MAPK Signaling Pathway
WP366	TGF beta Signaling Pathway
WP364	IL-6 signaling pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP306	Focal Adhesion
WP304	Kit receptor signaling pathway
WP286	IL-3 Signaling Pathway
WP2828	Bladder Cancer
WP2795	Cardiac Hypertrophic Response
WP2792	MAP kinase activation in TLR cascade
WP2735	RAF/MAP kinase cascade
WP2643	Nanoparticle-mediated activation of receptor signaling
WP2637	Structural Pathway of Interleukin 1 (IL-1)
WP2636	Genes and (Common) Pathways Underlying Drug Addiction
WP259	Nifedipine Activity
WP2586	Aryl Hydrocarbon Receptor
WP2526	PDGF Pathway
WP2380	BDNF signaling pathway
WP2377	Integrated Pancreatic Cancer Pathway
WP2374	Oncostatin M Signaling Pathway
WP2355	Corticotropin-releasing hormone
WP2332	Interleukin-11 Signaling Pathway
WP2324	AGE/RAGE pathway
WP23	B Cell Receptor Signaling Pathway
WP2263	Prostate Cancer
WP2261	Signaling Pathways in Glioblastoma
WP2203	TSLP Signaling Pathway
WP22	IL-9 Signaling Pathway
WP2197	Endothelin Pathways
WP205	IL-7 Signaling Pathway
WP2034	Leptin signaling pathway
WP2032	TSH signaling pathway
WP2018	RANKL/RANK Signaling Pathway
WP195	IL-1 signaling pathway
WP1911	Signaling by FGFR
WP185	Integrin-mediated Cell Adhesion
WP1843	L1CAM interactions
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1449	Regulation of toll-like receptor signaling pathway
WP1434	Osteopontin Signaling
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T35940
UNIPROID	MP2K1_HUMAN
TARGNAME	ERK activator kinase 1 (MEK1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
ERK activator kinase 1 (MEK1)	MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

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