TARGETID

T35734

FORMERID

TTDR01203

UNIPROID

HYES_HUMAN

TARGNAME

Soluble epoxide hydrolase (EPHX2)

GENENAME

EPHX2

TARGTYPE

Clinical trial target

SYNONYMS

Bifunctional epoxide hydrolase 2

FUNCTION

Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid.

PDBSTRUC

6AUM; 5MWA; 5FP0; 5AM5; 5AM4

BIOCLASS

Ether bond hydrolase

SEQUENCE

MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM

DRUGINFO

AR9281

DRUGINFO

GSK2256294

DRUGINFO

[4-(3-Adamantan-1-yl-ureido)-phenyl]-acetic acid

DRUGINFO

1-(1-Adamantyl)-3-(1-propionylpiperidin-4-yl)urea

DRUGINFO

1-(1-Propionylpiperidin-4-yl)-3-m-tolylurea

DRUGINFO

1-(1-Propionylpiperidin-4-yl)-3-o-tolylurea

DRUGINFO

1-(1-Propionylpiperidin-4-yl)-3-p-tolylurea

DRUGINFO

1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea

DRUGINFO

1-(3-Chloro-phenyl)-3-(4-hydroxy-decyl)-urea