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靶点信息32(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Dual specificity protein phosphatase 1 (DUSP1)
TARGTYPE
Clinical trial target
SYNONYMS
VH1; Protein-tyrosine phosphatase CL100; PTPN10; Mitogen-activated protein kinase phosphatase 1; MKP1; MKP-1; MAP kinase phosphatase-1; MAP kinase phosphatase 1; Dual specificity protein phosphatase hVH1; CL100
FUNCTION
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
PDBSTRUC
6D67; 6D66; 6D65; 6APX
BIOCLASS
Phosphoric monoester hydrolase
SEQUENCE
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
DRUGINFO
Avastin+/-Tarceva
DRUGINFO
4-ethoxynaphthalene-1,2-dione
KEGGPATH
hsa04010:MAPK signaling pathway
KEGGPATH
hsa04726:Serotonergic synapse
WIKIPATH
WP382:MAPK Signaling Pathway
REACPATH
R-HSA-112409:RAF-independent MAPK1/3 activation
目标的蛋白质ID
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目标的序列数据
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| Dual specificity protein phosphatase 1 (DUSP1) |
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