TARGETID

T35040

FORMERID

TTDNR00648

UNIPROID

BASI_HUMAN

TARGNAME

Basigin (BSG)

GENENAME

BSG

TARGTYPE

Clinical trial target

SYNONYMS

UNQ6505/PRO21383; Tumor cell-derived collagenase stimulatory factor; TCSF; OK blood group antigen; Leukocyte activation antigen M6; Extracellular matrix metalloproteinase inducer; EMMPRIN; 5F7

FUNCTION

Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane.

PDBSTRUC

5XF0; 5X0T; 4U0Q; 3QR2; 3QQN

BIOCLASS

Basigin protein

SEQUENCE

MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS

DRUGINFO

Gavilimomab

DRUGINFO

[131I]-Metuximab

WIKIPATH

WP129:Matrix Metalloproteinases

WIKIPATH

WP1794:Cell surface interactions at the vascular wall

WIKIPATH

WP1833:Integrin cell surface interactions

WIKIPATH

WP2766:The citric acid (TCA) cycle and respiratory electron transport

REACPATH

R-HSA-1474228:Degradation of the extracellular matrix

REACPATH

R-HSA-210991:Basigin interactions

REACPATH

R-HSA-216083:Integrin cell surface interactions