TARGETID

T34296

FORMERID

TTDC00150

UNIPROID

MMP13_HUMAN

TARGNAME

Matrix metalloproteinase-13 (MMP-13)

GENENAME

MMP13

TARGTYPE

Clinical trial target

SYNONYMS

Matrix metalloproteinase 13; Collagenase-3; Collagenase 3

FUNCTION

Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN.

PDBSTRUC

830C; 5UWN; 5UWM; 5UWL; 5UWK

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.24.-

SEQUENCE

MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC

DRUGINFO

Curcumin

DRUGINFO

Apratastat

DRUGINFO

PMID17935984C1

DRUGINFO

PMID29130358-Compound-Figure16(9a)

DRUGINFO

PMID29130358-Compound-Figure16(9b)

DRUGINFO

PMID29130358-Compound-Figure16(9c)

DRUGINFO

PMID29130358-Compound-Figure18(14)

DRUGINFO

PMID29130358-Compound-Figure18(14a)