TARGETID

T33990

FORMERID

TTDC00263

UNIPROID

CSF1_HUMAN

TARGNAME

Macrophage colony-stimulating factor 1 (CSF1)

GENENAME

CSF1

TARGTYPE

Clinical trial target

SYNONYMS

Processed macrophagecolony-stimulating factor 1; MCSF; M-CSF; Lanimostim; CSF-1

FUNCTION

Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.

PDBSTRUC

5LXF; 4WRM; 4WRL; 4FA8; 4ADF

SEQUENCE

MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV

DRUGINFO

RG7155

DRUGINFO

Emactuzumab

DRUGINFO

MSC110

DRUGINFO

PLX73086

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04380:Osteoclast differentiation

KEGGPATH

hsa04640:Hematopoietic cell lineage