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靶点信息14(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Mcl-1 messenger RNA (MCL-1 mRNA)
TARGTYPE
Successful target
SYNONYMS
mcl1/EAT (mRNA); Induced myeloid leukemia cell differentiation protein Mcl-1 (mRNA); Bcl2-L-3 (mRNA); Bcl-2-related protein EAT/mcl1 (mRNA); Bcl-2-like protein 3 (mRNA); BCL2L3 (mRNA)
FUNCTION
Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation.
PDBSTRUC
6OVC; 6OQN; 6OQD; 6OQC; 6OQB
SEQUENCE
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
DRUGINFO
MCL-1-specific antisense oligonucleotide + midostaurin(PKC412)
DRUGINFO
MCL-1-specific antisense oligonucleotide + nilotinib (AMN107)
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Mcl-1 messenger RNA (MCL-1 mRNA) |
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