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靶点信息24(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
D-amino acid oxidase (DAO)
TARGTYPE
Clinical trial target
SYNONYMS
Daminoacid oxidase; DAMOX; DAAO
FUNCTION
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
PDBSTRUC
5ZJA; 5ZJ9; 4QFD; 4QFC; 3ZNQ
BIOCLASS
CH-NH(2) donor oxidoreductase
SEQUENCE
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
KEGGPATH
hsa00260:Glycine, serine and threonine metabolism
KEGGPATH
hsa00330:Arginine and proline metabolism
KEGGPATH
hsa00472:D-Arginine and D-ornithine metabolism
KEGGPATH
hsa01100:Metabolic pathways
KEGGPATH
hsa01130:Biosynthesis of antibiotics
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00260 |
|
| hsa00330 |
|
| hsa00472 |
|
| hsa01100 |
|
| hsa01130 |
|
| hsa04146 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| D-amino acid oxidase (DAO) |
|