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靶点信息21(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGTYPE
Clinical trial target
SYNONYMS
Protease, cysteine 1; PRSC1; Asparaginyl endopeptidase
FUNCTION
Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Has a strict specificity for hydrolysis of asparaginyl bonds.
PDBSTRUC
5LUB; 5LUA; 5LU9; 5LU8; 4N6O
SEQUENCE
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
DRUGINFO
Legumain-cleavable doxorubicin prodrugs
KEGGPATH
hsa04142:Lysosome
KEGGPATH
hsa04612:Antigen processing and presentation
WIKIPATH
WP2679:MHC class II antigen presentation
WIKIPATH
WP2749:Metabolism of steroid hormones and vitamin D
REACPATH
R-HSA-1679131:Trafficking and processing of endosomal TLR
REACPATH
R-HSA-196791:Vitamin D (calciferol) metabolism
目标的蛋白质ID
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