TARGETID

T32780

UNIPROID

ASGR1_HUMAN

TARGNAME

Asialoglycoprotein receptor 1 (ASGR1)

GENENAME

ASGR1

TARGTYPE

Clinical trial target

SYNONYMS

Hepatic lectin H1; HL-1; C-type lectin domain family 4 member H1

FUNCTION

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

PDBSTRUC

5JQ1; 5JPV; 1DV8

SEQUENCE

MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

DRUGINFO

AMG 529

KEGGPATH

hsa04918:Thyroid hormone synthesis