TARGETID

T31989

FORMERID

TTDC00058

UNIPROID

SPHK2_HUMAN

TARGNAME

Sphingosine kinase 2 (SPHK2)

GENENAME

SPHK2

TARGTYPE

Clinical trial target

SYNONYMS

SPK 2; SK 2

FUNCTION

Acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions.

BIOCLASS

Kinase

ECNUMBER

EC 2.7.1.91

SEQUENCE

MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTYPRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP

DRUGINFO

ABC294640

DRUGINFO

(R)-2-amino-3-(4-octylphenylamino)propan-1-ol

DRUGINFO

(R)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide

DRUGINFO

(S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide

DRUGINFO

(S)-2-amino-6-hydroxy-N-(4-octylphenyl)hexanamide

DRUGINFO

DIMETHYLSPINGOSINE

DRUGINFO

ROMe

KEGGPATH

hsa00600:Sphingolipid metabolism

KEGGPATH

hsa01100:Metabolic pathways