当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话13136136841)
靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Calcium-release activated calcium channel (CRACM)
TARGTYPE
Clinical trial target
SYNONYMS
Transmembrane protein 142A; TMEM142A; Protein orai-1; Calcium release-activated calcium channel protein 1; CRACM1
FUNCTION
CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1.
SEQUENCE
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
KEGGPATH
hsa04020:Calcium signaling pathway
KEGGPATH
hsa04024:cAMP signaling pathway
KEGGPATH
hsa04611:Platelet activation
KEGGPATH
hsa05340:Primary immunodeficiency
WIKIPATH
WP1885:Platelet homeostasis
WIKIPATH
WP2746:Signaling by the B Cell Receptor (BCR)
REACPATH
R-HSA-983695:Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
INTEPATH
cd8tcrpathway:TCR signaling in naïve CD8+ T cells
INTEPATH
tcr_pathway:TCR signaling in naïve CD4+ T cells
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04020 |
|
| hsa04024 |
|
| hsa04611 |
|
| hsa05340 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Calcium-release activated calcium channel (CRACM) |
|