TARGETID

T30082

FORMERID

TTDS00140

UNIPROID

ACES_HUMAN

TARGNAME

Acetylcholinesterase (AChE)

GENENAME

ACHE

TARGTYPE

Successful target

SYNONYMS

YT; N-ACHE; ARACHE

FUNCTION

Role in neuronal apoptosis. Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

PDBSTRUC

6O69; 6F25; 6CQZ; 6CQY; 6CQX

BIOCLASS

Carboxylic ester hydrolase

ECNUMBER

EC 3.1.1.7

SEQUENCE

MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL

DRUGINFO

Ambenonium

DRUGINFO

Demecarium bromide

DRUGINFO

Donepezil

DRUGINFO

Echothiophate Iodide

DRUGINFO

Edrophonium

DRUGINFO

Galantamine

DRUGINFO

Huperzine A

DRUGINFO

Isoflurophate