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靶点信息25(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Wilms tumor protein (WT1)
TARGTYPE
Clinical trial target
SYNONYMS
Wilms' tumour 1 protein; WT33; WT1 protein
FUNCTION
Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. Transcription factor that plays an important role in cellular development and cell survival.
PDBSTRUC
6BLW; 6B0R; 6B0Q; 6B0P; 6B0O
BIOCLASS
EGR C2H2-type zinc-finger
SEQUENCE
MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
DRUGINFO
Combined PR1/WT1 vaccine
DRUGINFO
WT1 peptide vaccine
DRUGINFO
WT1-targeted autologous dendritic cell vaccine
KEGGPATH
hsa05202:Transcriptional misregulation in cancer
WIKIPATH
WP2377:Integrated Pancreatic Cancer Pathway
目标的蛋白质ID
| 标题 | 内容 |
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Wilms tumor protein (WT1) |
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