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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
O-6-methylguanine-DNA-alkyltransferase (MGMT)
TARGTYPE
Clinical trial target
SYNONYMS
Methylated-DNA--protein-cysteine methyltransferase; Human O(6)-alkylguanine-DNA alkyltransferase; 6-O-methylguanine-DNA methyltransferase
FUNCTION
Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.
PDBSTRUC
1YFH; 1T39; 1T38; 1QNT; 1EH8
BIOCLASS
Methyltransferase
SEQUENCE
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
DRUGINFO
O6-Benzylguanine alkylade
DRUGINFO
6-Allyloxy-9H-purin-2-ylamine
DRUGINFO
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine
DRUGINFO
6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine
DRUGINFO
6-Benzyloxy-9H-purin-2-ylamine
DRUGINFO
S-Methylcysteine
WIKIPATH
WP1804:DNA Damage Reversal
目标的蛋白质ID
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目标的序列数据
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| O-6-methylguanine-DNA-alkyltransferase (MGMT) |
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