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靶点信息18(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Lysosomal acid lipase (LIPA)
TARGTYPE
Successful target
SYNONYMS
Sterol esterase; Lysosomal acid lipase/cholesteryl ester hydrolase; Lipase A; LIPA; LAL; Cholesteryl esterase; Acid cholesteryl ester hydrolase
FUNCTION
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
BIOCLASS
Carboxylic ester hydrolase
SEQUENCE
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
KEGGPATH
hsa00100:Steroid biosynthesis
KEGGPATH
hsa04142:Lysosome
WIKIPATH
WP136:Phase I biotransformations, non P450
WHIZPATH
PW000050:Steroid Biosynthesis
WHIZPATH
PW000145:Bile Acid Biosynthesis
PANTPATH
P02727:Androgen/estrogene/progesterone biosynthesis
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Lysosomal acid lipase (LIPA) |
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