TARGETID

T23499

FORMERID

TTDS00198

UNIPROID

EDNRA_HUMAN

TARGNAME

Endothelin A receptor (EDNRA)

GENENAME

EDNRA

TARGTYPE

Successful target

SYNONYMS

HET-AR; Endothelin-1 receptor; Endothelin receptor type A; Endothelin receptor A; ETRA; ETA-R; ETA receptor; ETA; ET-A

FUNCTION

Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Receptor for endothelin-1.

BIOCLASS

GPCR rhodopsin

SEQUENCE

METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN

DRUGINFO

Ambrisentan

DRUGINFO

Bosentan

DRUGINFO

LU302146

DRUGINFO

Macitentan

DRUGINFO

Atrasentan

DRUGINFO

Clazosentan

DRUGINFO

Darusentan

DRUGINFO

PF-1228305

DRUGINFO

sparsentan

DRUGINFO

BQ-123