靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T23471

FORMERID

TTDC00199

UNIPROID

PERM_HUMAN

TARGNAME

Myeloperoxidase (MPO)

GENENAME

MPO

TARGTYPE

Clinical trial target

SYNONYMS

MPO

FUNCTION

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acidin physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

PDBSTRUC

6BMT; 6AZP; 5UZU; 5MFA; 5FIW

BIOCLASS

Peroxidases

ECNUMBER

EC 1.11.2.2

SEQUENCE

MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS

DRUGINFO

E-101

DRUGINFO

AZD-3241

DRUGINFO

AZD4831

DRUGINFO

AZD5904

Discontinued in Phase 1

DRUGINFO

D05OZR

4-aminobenzoic acid hydrazide

Investigative

DRUGINFO

D01ZZG

INV-311

Investigative

KEGGPATH

hsa04145:Phagosome

KEGGPATH

hsa05202:Transcriptional misregulation in cancer

目标的 KEGG 通路数据

标题	内容
hsa04145	Phagosome
hsa05202	Transcriptional misregulation in cancer

目标的 Wiki 路径数据

标题	内容
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T23471
UNIPROID	PERM_HUMAN
TARGNAME	Myeloperoxidase (MPO)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Myeloperoxidase (MPO)	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS

标题

内容

Myeloperoxidase (MPO)

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