TARGETID

T23292

FORMERID

TTDI02272

UNIPROID

GALNS_HUMAN

TARGNAME

N-acetylgalactosamine 6 sulfatase (GALNS)

GENENAME

GALNS

TARGTYPE

Successful target

SYNONYMS

N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfatase; Galactose-6-sulfate sulfatase; GalNAc6S sulfatase; GalN6S; Chondroitinsulfatase; Chondroitinase

FUNCTION

Catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate.

PDBSTRUC

4FDJ; 4FDI

BIOCLASS

Sulfuric ester hydrolase

ECNUMBER

EC 3.1.6.4

SEQUENCE

MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH

DRUGINFO

Elosulfase alfa

DRUGINFO

BMN-110

KEGGPATH

hsa00531:Glycosaminoglycan degradation

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa04142:Lysosome

BIOCPATH

PWY-6573:Chondroitin sulfate degradation (metazoa)