靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

WIKIPATH

WP734:Serotonin Receptor 4/6/7 and NR3C Signaling

WIKIPATH

WP75:Toll-like receptor signaling pathway

REACPATH

R-HSA-110056:MAPK3 (ERK1) activation

REACPATH

R-HSA-112409:RAF-independent MAPK1/3 activation

REACPATH

R-HSA-1169408:ISG15 antiviral mechanism

REACPATH

R-HSA-198753:ERK/MAPK targets

REACPATH

R-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation

REACPATH

R-HSA-2559580:Oxidative Stress Induced Senescence

REACPATH

R-HSA-2559582:Senescence-Associated Secretory Phenotype (SASP)

REACPATH

R-HSA-2559585:Oncogene Induced Senescence

REACPATH

R-HSA-2871796:FCERI mediated MAPK activation

REACPATH

R-HSA-3371453:Regulation of HSF1-mediated heat shock response

REACPATH

R-HSA-375165:NCAM signaling for neurite out-growth

REACPATH

R-HSA-450341:Activation of the AP-1 family of transcription factors

REACPATH

R-HSA-456926:Thrombin signalling through proteinase activated receptors (PARs)

REACPATH

R-HSA-5654726:Negative regulation of FGFR1 signaling

REACPATH

R-HSA-5654727:Negative regulation of FGFR2 signaling

REACPATH

R-HSA-5654732:Negative regulation of FGFR3 signaling

REACPATH

R-HSA-5654733:Negative regulation of FGFR4 signaling

REACPATH

R-HSA-5663213:RHO GTPases Activate WASPs and WAVEs

目标的 KEGG 通路数据

标题	内容
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04024	cAMP signaling pathway
hsa04062	Chemokine signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04114	Oocyte meiosis
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04270	Vascular smooth muscle contraction
hsa04320	Dorso-ventral axis formation
hsa04350	TGF-beta signaling pathway
hsa04360	Axon guidance
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04540	Gap junction
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04611	Platelet activation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04668	TNF signaling pathway
hsa04713	Circadian entrainment
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04723	Retrograde endocannabinoid signaling
hsa04724	Glutamatergic synapse
hsa04725	Cholinergic synapse
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04915	Estrogen signaling pathway
hsa04916	Melanogenesis
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04930	Type II diabetes mellitus
hsa04960	Aldosterone-regulated sodium reabsorption
hsa05010	Alzheimer's disease
hsa05020	Prion diseases
hsa05034	Alcoholism
hsa05131	Shigellosis
hsa05132	Salmonella infection
hsa05133	Pertussis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05218	Melanoma
hsa05219	Bladder cancer

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP734	Serotonin Receptor 4/6/7 and NR3C Signaling
WP732	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP722	Serotonin HTR1 Group and FOS Pathway
WP69	TCR Signaling Pathway
WP666	Hypothetical Network for Drug Addiction
WP581	EPO Receptor Signaling
WP560	TGF Beta Signaling Pathway
WP51	Regulation of Actin Cytoskeleton
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP422	MAPK Cascade
WP395	IL-4 Signaling Pathway
WP382	MAPK Signaling Pathway
WP364	IL-6 signaling pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP304	Kit receptor signaling pathway
WP2868	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
WP286	IL-3 Signaling Pathway
WP2795	Cardiac Hypertrophic Response
WP2792	MAP kinase activation in TLR cascade
WP2759	Fc epsilon receptor (FCERI) signaling
WP2735	RAF/MAP kinase cascade
WP2637	Structural Pathway of Interleukin 1 (IL-1)
WP2636	Genes and (Common) Pathways Underlying Drug Addiction
WP26	Signal Transduction of S1P Receptor
WP2526	PDGF Pathway
WP244	Alpha 6 Beta 4 signaling pathway
WP2431	Spinal Cord Injury
WP2380	BDNF signaling pathway
WP2377	Integrated Pancreatic Cancer Pathway
WP2374	Oncostatin M Signaling Pathway
WP2355	Corticotropin-releasing hormone
WP2332	Interleukin-11 Signaling Pathway
WP2324	AGE/RAGE pathway
WP231	TNF alpha Signaling Pathway
WP2263	Prostate Cancer
WP2261	Signaling Pathways in Glioblastoma
WP2203	TSLP Signaling Pathway
WP22	IL-9 Signaling Pathway
WP2112	IL17 signaling pathway
WP2059	Alzheimers Disease
WP205	IL-7 Signaling Pathway
WP2036	TWEAK Signaling Pathway
WP2035	FSH signaling pathway
WP2034	Leptin signaling pathway
WP2018	RANKL/RANK Signaling Pathway
WP195	IL-1 signaling pathway
WP1929	Thrombin signalling through proteinase activated receptors (PARs)
WP1913	Signaling by Insulin receptor
WP1911	Signaling by FGFR
WP1905	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1843	L1CAM interactions
WP1781	Advanced glycosylation endproduct receptor signaling
WP1772	Apoptosis Modulation and Signaling
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1449	Regulation of toll-like receptor signaling pathway
WP1434	Osteopontin Signaling
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T23276
UNIPROID	MK03_HUMAN
TARGNAME	Extracellular signal-regulated kinase 1 (ERK1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Extracellular signal-regulated kinase 1 (ERK1)	MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP

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