TARGETID

T23212

FORMERID

TTDR00283

UNIPROID

CD14_HUMAN

TARGNAME

Monocyte differentiation antigen CD14 (CD14)

GENENAME

CD14

TARGTYPE

Clinical trial target

SYNONYMS

Myeloid cell-specific leucine-rich glycoprotein

FUNCTION

In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). Coreceptor for bacterial lipopolysaccharide.

PDBSTRUC

4GLP

SEQUENCE

MERASCLLLLLLPLVHVSATTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACARSTLSVGVSGTLVLLQGARGFA

DRUGINFO

IC14

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04064:NF-kappa B signaling pathway

KEGGPATH

hsa04145:Phagosome

KEGGPATH

hsa04620:Toll-like receptor signaling pathway

KEGGPATH

hsa04640:Hematopoietic cell lineage

KEGGPATH

hsa04810:Regulation of actin cytoskeleton

KEGGPATH

hsa05130:Pathogenic Escherichia coli infection

KEGGPATH

hsa05132:Salmonella infection

KEGGPATH

hsa05133:Pertussis