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靶点信息30(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cholesterol desmolase (CYP11A1)
TARGTYPE
Successful target
SYNONYMS
P450(scc); Cytochrome P450(scc); Cytochrome P450 11A1; Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; CYP11A
FUNCTION
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones.
PDBSTRUC
3NA1; 3NA0; 3N9Z; 3N9Y
BIOCLASS
Paired donor oxygen oxidoreductase
SEQUENCE
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
DRUGINFO
Aminoglutethimide
DRUGINFO
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione
DRUGINFO
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione
KEGGPATH
hsa00140:Steroid hormone biosynthesis
KEGGPATH
hsa01100:Metabolic pathways
KEGGPATH
hsa04913:Ovarian steroidogenesis
WIKIPATH
WP1879:Phase 1 - Functionalization of compounds
WIKIPATH
WP2355:Corticotropin-releasing hormone
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00140 |
|
| hsa01100 |
|
| hsa04913 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP98 |
|
| WP702 |
|
| WP43 |
|
| WP2749 |
|
| WP237 |
|
| WP2355 |
|
| WP1879 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Cholesterol desmolase (CYP11A1) |
|