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靶点信息

标题

内容

相关药物

状态

TARGETID

T22976

FORMERID

TTDR00783

UNIPROID

KITM_HUMAN

TARGNAME

Thymidine kinase 2 (Mt-TK2)

GENENAME

dnk

TARGTYPE

Clinical trial target

SYNONYMS

dnk; Multispecific deoxynucleoside kinase; Dm-Dnk; Deoxyribonucleoside kinase

FUNCTION

Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.

BIOCLASS

Kinase

ECNUMBER

EC 2.7.1.21

SEQUENCE

MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP

DRUGINFO

DI4SM3

MT-1621

Phase 3

DRUGINFO

D0I6UV

1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine

Investigative

DRUGINFO

D00KWL

1-[5-(triphenylmethoxy)pentyl]thymine

Investigative

DRUGINFO

D02CCD

1-[6-(triphenylmethoxy)hexyl]thymine

Investigative

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T22976
UNIPROID	KITM_HUMAN
TARGNAME	Thymidine kinase 2 (Mt-TK2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Thymidine kinase 2 (Mt-TK2)	MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP

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