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靶点信息16(本栏目收费,不能显示细节,电话13136136841)

靶点信息

标题

内容

相关药物

状态

TARGETID

T22956

FORMERID

TTDI02041

UNIPROID

CDK3_HUMAN

TARGNAME

Cyclin-dependent kinase 3 (CDK3)

GENENAME

CDK3

TARGTYPE

Clinical trial target

SYNONYMS

Cyclindependent kinase 3; Cell division protein kinase 3; CDKN3

FUNCTION

Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions.

PDBSTRUC

1LFN

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.22

SEQUENCE

MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH

DRUGINFO

D03DKV

RGB-286638

Phase 1

DRUGINFO

D0LK4L

Nitrogen mustard derivative 1

Patented

DRUGINFO

D0M5DX

Oxazolyl methylthiothiazole derivative 1

Patented

DRUGINFO

D0FQ6V

PMID26161698-Compound-17

Patented

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T22956
UNIPROID	CDK3_HUMAN
TARGNAME	Cyclin-dependent kinase 3 (CDK3)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Cyclin-dependent kinase 3 (CDK3)	MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH

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