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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Mucosal addressin cell adhesion molecule 1 (MADCAM1)
TARGTYPE
Clinical trial target
SYNONYMS
hMAdCAM-1; MAdCAM-1; MADCAM1
FUNCTION
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
PDBSTRUC
4HD9; 4HCR; 4HC1; 4HBQ; 1GSM
SEQUENCE
MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQLLVYAFPDQLTVSPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGDEDVLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHRQAIPVLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLLALPTYHLWKRCRHLAEDDTHPPASLRLLPQVSAWAGLRGTGQVGISPS
KEGGPATH
hsa04514:Cell adhesion molecules (CAMs)
KEGGPATH
hsa04672:Intestinal immune network for IgA production
NET_PATH
NetPath_9:TNFalpha Signaling Pathway
INTEPATH
a4b7_pathway:a4b7 Integrin signaling
INTEPATH
integrin5_pathway:Beta5 beta6 beta7 and beta8 integrin cell surface interactions
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Mucosal addressin cell adhesion molecule 1 (MADCAM1) |
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