TARGETID

T21782

FORMERID

TTDI00605

UNIPROID

PCNA_HUMAN

TARGNAME

Proliferating cell nuclear antigen (PCNA)

GENENAME

PCNA

TARGTYPE

Clinical trial target

SYNONYMS

Cyclin

FUNCTION

Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

PDBSTRUC

6QCG; 6QC0; 6HVO; 6GWS; 6GIS

SEQUENCE

MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS

DRUGINFO

ATX-101

DRUGINFO

ChelASE

KEGGPATH

hsa03030:DNA replication

KEGGPATH

hsa03410:Base excision repair

KEGGPATH

hsa03420:Nucleotide excision repair

KEGGPATH

hsa03430:Mismatch repair

KEGGPATH

hsa04110:Cell cycle

KEGGPATH

hsa05161:Hepatitis B

KEGGPATH

hsa05166:HTLV-I infection

WIKIPATH

WP1787:Base Excision Repair