TARGETID

T21678

FORMERID

TTDC00016

UNIPROID

AGAL_HUMAN

TARGNAME

Alpha-galactosidase A (GLA)

GENENAME

GLA

TARGTYPE

Successful target

SYNONYMS

Melibiase; INN=Agalsidase; Alpha-D-galactoside galactohydrolase; Alpha-D-galactosidase A

FUNCTION

A homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Predominantly hydrolyzes ceramide trihexoside, and can catalyze the hydrolysis of melibiose into galactose and glucose.

PDBSTRUC

4NXS; 3TV8; 3S5Z; 3S5Y; 3LXC

BIOCLASS

Glycosylase

ECNUMBER

EC 3.2.1.22

SEQUENCE

MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL

DRUGINFO

Migalastat

DRUGINFO

AVR-RD-01

DRUGINFO

PRX-102

DRUGINFO

(+)-5-deoxyadeenophorine

DRUGINFO

2,5-dideoxy-2,5-imino-D-altritol

DRUGINFO

Alpha-D-Mannose

DRUGINFO

Beta-1-C-butenyl-1-deoxygalactonojirimycin

DRUGINFO

Beta-1-C-Butyl-1-deoxygalactonojirimycin