TARGETID

T21334

FORMERID

TTDC00224

UNIPROID

TNF11_HUMAN

TARGNAME

Osteoclast differentiation factor (ODF)

GENENAME

TNFSF11

TARGTYPE

Successful target

SYNONYMS

Tumor necrosis factor ligand superfamily member 11; TRANCE; TNF-related activation-induced cytokine; Receptor activatorof nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; RANKL; Osteoprotegerin ligand; OPGL; CD254

FUNCTION

Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.

PDBSTRUC

5BNQ; 3URF

BIOCLASS

Cytokine: tumor necrosis factor

SEQUENCE

MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID

DRUGINFO

Denosumab

DRUGINFO

ALX-0141

DRUGINFO

CEP-37251

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04064:NF-kappa B signaling pathway

KEGGPATH

hsa04380:Osteoclast differentiation

KEGGPATH

hsa04917:Prolactin signaling pathway

KEGGPATH

hsa05323:Rheumatoid arthritis

WIKIPATH

WP12:Osteoclast Signaling