TARGETID

T20761

FORMERID

TTDNS00542

UNIPROID

VEGFA_HUMAN

TARGNAME

Vascular endothelial growth factor A (VEGFA)

GENENAME

VEGFA

TARGTYPE

Successful target

SYNONYMS

Vascular permeability factor; VPF; VEGF-A; VEGF

FUNCTION

Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.

PDBSTRUC

6D3O; 6BFT; 5T89; 5O4E; 5HHD

BIOCLASS

Growth factor

SEQUENCE

MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

DRUGINFO

Aflibercept

DRUGINFO

Bevacizumab

DRUGINFO

Brolucizumab

DRUGINFO

Ranibizumab

DRUGINFO

Avastin+/-Tarceva

DRUGINFO

Bevacizumab + Erlotinib

DRUGINFO

Bevacizumab + Rituximab

DRUGINFO

Bevacizumab + Trastuzumab

DRUGINFO

Faricimab